Thomas A. Ban’s final reply to William Bunney's final comment


Thomas A. Ban: From Melancholia to Depression
A History of Diagnosis and Treatment
Collated by Olaf Fjetland


            Thank you for your recognition of my long time interest in identifying treatment responsive subpopulations within psychiatric diagnoses.

            I will follow with interest whether the finding of “a subgroup of treatment-resistant MDDs who show a rapid and dramatic response to low-dose ketamine” could be verified.  

            I think your report with Goodwin and Murphy in the late 1960s in which you verified, in a placebo-controlled study,  lithium’s  ”unequivocal” therapeutic efficacy in “bipolar depression,, i.e., in “typical “ MDP patients, with a history of both, “manic” and “depressive” episodes,  remains  the most significant contribution in this area of research to date (Goodwin, Murphy and Bunney, 1969).



Goodwin, FK, Murphy DL, Bunney WEJr. Lithium carbonate treatment in depression and mania. A longitudinal double-blind study. Arch Gen Psychiatry 1969; 21:486-96. 


November 2, 2017