Thomas A. Ban’s Final Reply to Gordon Johnson's Final Comment
Thomas A. Ban: From Melancholia to Depression
A History of Diagnosis and Treatment
Collated by Olaf Fjetland


Thank you for your comment. We agree: the pathophysiology of depression remains unknown and in the absence of a biological marker, the diagnostic criteria remain provisional and their validity uncertain. It seems the pharmacological heterogeneity of “depression - melancholia” precludes the possibility for identifying a biological marker for the diagnosis.


March 8, 2018